The Effect of Epinephrine Administration on the Level of Gonadotropin Hormones of Japan Strain Female Mice (Mus Musculus)

Physical, chemical, and psychological stressors can affect the pulsatile frequency and amplitude of GnRH;
this is important for FSH and LH secretion. Excessive increase in pulsation can reduce and stop FSH and
LH secretion. This study aimed to prove the effect of epinephrine to FSH and LH levels. This study was an
experimental laboratory with a post-test only control group design. This study used 24 female mice (Mus
musculus) consisting of 6 groups, namely 1 control group and 5 treatment groups based on differences in the
administration of epinephrine of 0.001 mg/ml, 0.002 mg/ml, 0.003 mg/ml, 0.004 mg/ml, and 0.005 mg/ml
applied every day for 20 days starting at the beginning of the pro-estrus cycle. The results were analyzed
using the One-Way ANOVA continued Multiple Comparisons Bonferroni test. The results showed that the
dose difference in the administration of epinephrine gave a significant difference (p <0.05) on FSH and LH
levels starting at 0.001 mg/ml and 0.002 mg/ml, 0.003 mg/ml, 0.004 mg/ml, 0.005 mg/ml with control. It
can be concluded that chemical stressors (epinephrine) can reduce FSH and LH levels. It is recommended
that further research adds measurements on the levels of estrogen and progesterone and the levels of
catecholamine.
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