Follicle Stimulating Hormone Receptor Ser680Asn Polymorphism in Women With Polycystic Ovary

Ahda, Yuni (2014) Follicle Stimulating Hormone Receptor Ser680Asn Polymorphism in Women With Polycystic Ovary. In: Global Trenda and Issues on Mathematics and Science and The Education, 18-20 May 2014, Yogjakarta.

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Abstract

Polymorphisms at codon 680 (Ser680Asn) of FSH receptor gene affected the basal FSH levels and sensitivity of FSH receptor to FSH exogenous in women undergoing assisted reproduction program in some ethnics in the world, while it could not proved in others. This study aims to determine the association of polymorphisms Ser680Asn in patients with polycystic ovary (PCO) in Indonesian population. The study involved 30 PCO patients and 30 normal women. Polymorphisms analysis was performed by PCR - RFLP. ELISA was used to detect FSH level. Statistical analysis was done by chi - square and t tests. This study shows the homozygote variant Ser/Ser is significantly different in distribution between patients and normal women where it is more frequent in PCO women. In normal women, the three allelic variant distributed normally. There is no significant different in FSH level in three genotipe between patients and normal women. Conclution: There is a significant different in genotype distribution of FSH receptor gene between PCO patients and normal women for polymorphism at codon 680 but it was not associated with FSH level

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