Latihan Fisik dan Kalsitonin Salmon Meningkatkan Kepadatan Tulang Tikus Masa Pertumbuhan (Exercise and Salmon Calcitonin Increase Bone Density In Growing Rat)

Lesmana, Heru Syarli and Sari, Gadis M and Effendi, Choesnan (2015) Latihan Fisik dan Kalsitonin Salmon Meningkatkan Kepadatan Tulang Tikus Masa Pertumbuhan (Exercise and Salmon Calcitonin Increase Bone Density In Growing Rat). In: Prosidiing Kongres Nasional IAIFI XVI, Simposium, Seminar Nasional dan Workhop ke XXIV: Interaksi Holistik antara Organisme dan Lingkungan untuk Kualitas Hidup yang Lebih Baik: Ketahanan Pangan, Kesehataqn, dan Prestasi Olahraga, 29-31 Oktober 2015, Padang.

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Abstract

Bone is a complex tissue consists of cell and matrix. Matrix consist of fibers and ground substance that contain mineralized. Bone mineralized always increase and decrease through the remodelling process. Remodelling bone consists of two processes, bone formatted by osteoblast and bone resorption by osteoclast. Growing period is the best period to increase bone density. The research purpose was to prove exercise and calcitonin effect in the bone density and bone mass increment. The research method used the randomize post test only control group design. The groups consist of control, exercise, and combine (exercise+calcitonin) group. The sampel of each group is seven young males norvegicus rat (six weeks old). Exercise group swam once a day and three times a week, calsitonin group was given synthetic salmon calcitonin injection 2 IU/100gram of rat weight everyday and combine group was treated both of exercise and calcitonin injection. The treatment duration is eight weeks. Measurements of density bone was done with using ultrasound DBM SONIC 1200 (Digital Bone Measurement- emsor,SA,Madrid,spain). This instrument was issued conducting sound waves to assessment of density bone with m/sec. The research also measured mass , diameter and length of the bone. Mass bone was measured by using a analytical balance librar - shimadzu in grams. The result was the combine had higher bone density (p=0,001) and bone mass (p=0,004) compare to other groups. The conclusion was the combination of exercise and salmon calsitonin can increase bone density and bone mass in growing rat.

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