Latihan Fisik Intesitas Submaksimal dan Kalsitonin Salmon Meningkatkan Kepadatan Tulang Tikus Masa Pertumbuhan

Lesmana, Heru Syarli and Sari, Gadis M and Effendi, Choesnan and Arisandi, Shinta (2014) Latihan Fisik Intesitas Submaksimal dan Kalsitonin Salmon Meningkatkan Kepadatan Tulang Tikus Masa Pertumbuhan. Majalah Ilmu Faal Indonesia, 11 (1). ISSN 0215-1995

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Abstract

Bone is a complex tissue consisting of cells and matrix. Mass and thick bone mass has a dynamic addition and subtraction through the process of remodeling (bone matrix absorbed andformed again). Bone is formatted by osteoblast cell and resorption by osteoclast cell.Osteoblasts produce a matrix of osteoid, which is composed mainly of type I collagen, andosteoclast removes bone tissue by removing its mineralized matrix and breaking up the organicbone. Bone remodeling purpose to defend shape and structure of bone. the purpose of this study is to prove that submaximal-intensity exercise and salmon calcitonin improve bone density ingrowing rat this research method uses design of the randomize posttest only control groupdesign. We compered femur bone density in 24 male norvegicus rats aged 6 weeks that weredivided into 4 groups: controls, calcitonin, exercise, combine. Exercise group swam 3 times aweek in submaximal intensity, calcitonin group injected synthetic salmon calcitonin 2 iu /100gram of rat weight every day and combine group did both of it. After 8 weeks, rat femur bonedensity measured using ultrasound. the result: there are significant differences in bone densitybetween group 1 (control) and group 4 (combine) with p = 0.001, thus the p value <0.05indicates that there is a significant difference to the average density in both groups. Whilecomparisons to other groups found no significant difference because the value of p> 0.05. thebenefits of this research are calcitonin salmon and submaximal-intensity exercise increase thedensity bone in the growth period. High bone density is mean the bone is strong and health, notporous and fragile so decrease bone fracture risk. increase the bone density in of growth periodmake the bone get the best mass, and avoid from early osteoporosis.

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